Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor
In Reply: We agree with Dr Laheij that exploration
of heterogeneity sources may provide valuable information, especially for
controversial medical topics for which therapeutic or preventive effects of
different magnitude are obtained by different study designs.1
We also agree that empirical meta-analytic evaluations can be applied in other
types of studies as well.
Ioannidis JPA, Contopoulos-Ioannidis DG, Lau J. Using Meta-analysis to Answer Clinical Questions—Reply. JAMA. 2001;286(21):2669-2670. doi:10.1001/jama.286.21.2665