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December 26, 2001

Measuring the Quality of Trials of Treatments for Chronic Fatigue Syndrome—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;286(24):3078-3079. doi:10.1001/jama.286.24.3075

In Reply: The criteria for validity assessment in our systematic review are based on guidelines that have been recently updated and peer reviewed by international experts in systematic review methodology.1

To take each of Dr Goudsmit's points in turn:

First, Goudsmit's trial was nonrandomized, and compared an intervention group that had been diagnosed by a specialist to a waiting list control who had not been diagnosed. Consequently, the groups were likely to differ in terms of presence or severity of CFS. The groups were also unmatched for duration of illness, time on the waiting list and employment status.

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