Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor
In Reply: In response to Dr Pettilä, we
used the ICU mortality rate as our outcome measure, as the SOFA score is only
used in the intensive care setting. The attending physicians were unaware
of the daily SOFA scores, and the data collectors were not involved in patient
care or decision making.
We agree that the highest and mean SOFA scores, as well as the total
SOFA score, are biased in favor of death (even though we excluded data obtained
during the agonal period). For that reason, in addition to the fact that these
scores correlate highly with the other SOFA scores, we did not include them
in the multiple logistic regression presented herein.
Mélot C, Lopes-Ferreira F, Vincent J. Sequential Assessment of Multiple Organ Dysfunction as a Predictor of Outcome—Reply. JAMA. 2002;287(6):713-714. doi:10.1001/jama.287.6.711