Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor
In Reply: Dr Kent and Ms Brussel and colleagues
question our conclusion that formula feeding resulted in better health outcome
among participants in our randomized clinical trial than breastfeeding. We
respond by summarizing our key findings.
From these key findings, we concluded that formula feeding was associated
with better health outcome for HIV-1–infected mothers and their children
than breastfeeding in our trial.
Although formula feeding provided clear benefits, it also conferred
some risks, including higher incidence of dehydration and current diarrhea
during the first 3 months (but not subsequently), poorer nutritional status,
especially during the first 6 months, and a higher incidence of death due
to sepsis. Thus, we advocate careful follow-up of formula fed infants with
attention to these potential complications.
Mbori-Ngacha D, Nduati R, John-Stewart G, Richardson B, Kreiss J. Breastfeeding vs Formula-Feeding Among HIV-Infected Women in Resource-Poor Areas—Reply. JAMA. 2002;287(9):1110-1113. doi:10.1001/jama.287.9.1109