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March 27, 2002

Measurement of Serum Estradiol

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;287(12):1528. doi:10.1001/jama.287.12.1523

To the Editor: Dr Cummings and colleagues1 found that serum estradiol levels may be useful to identify women who would be most likely to benefit from prophylactic use of raloxifene to prevent breast cancer. Application of their results, however, which used a "sensitive" assay, may not be directly applicable to the commercially available assays for serum estradiol that are generally used in clinical practice. The apparent average value for estradiol in their population of postmenopausal women using this assay was 2.93 pg/mL, which is much lower than the range of 10 to 20 pg/mL used in daily clinical practice.2 Thus, their results must be adjusted before they can be applied to clinical practice.

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