Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor
To the Editor: Schrag et al1
recently found that short-course, high-dose amoxicillin therapy could decrease
the rate of carriage of penicillin-nonsusceptible Streptococcus
pneumoniae (PNSP) 28 days after treatment. We sought to determine whether
an increased dosage of amoxicillin for treatment of children can reduce community-wide
carriage of PNSP in a remote rural area.
Hennessy TW, Bruden D, Petersen KM, Parkinson AJ, Hurlburt D, Getty M, Butler JC, Schwartz B. Effect of High-Dose Amoxicillin on the Prevalence of Penicillin-Resistant Streptococcus pneumoniae in Rural Alaska. JAMA. 2002;287(16):2078-2079. doi:10.1001/jama.287.16.2073