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April 24, 2002

Effect of High-Dose Amoxicillin on the Prevalence of Penicillin-Resistant Streptococcus pneumoniae in Rural Alaska

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;287(16):2078-2079. doi:10.1001/jama.287.16.2073

To the Editor: Schrag et al1 recently found that short-course, high-dose amoxicillin therapy could decrease the rate of carriage of penicillin-nonsusceptible Streptococcus pneumoniae (PNSP) 28 days after treatment. We sought to determine whether an increased dosage of amoxicillin for treatment of children can reduce community-wide carriage of PNSP in a remote rural area.

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