Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor
In Reply: In response to Drs Rodriquez and
Calle, only 28% of the women enrolled in HERS had a BMI of 25 kg/m2
or less, and only 5% had a BMI of 20.9 kg/m2 or less. We examined
the quality-of-life measures in 3 strata of BMI: 25 kg/m2 or less,
more than 25 through 30 kg/m2, and more than 30 kg/m2.
Overall quality of life scores declined significantly with increasing BMI.
None of the tests for interaction between treatment assigned, follow-up time,
and BMI were statistically significant, however, and there were no consistent
trends between BMI and an effect of hormone therapy on quality of life.
Hlatky MA, Boothroyd D. Postmenopausal Hormone Replacement, Body Mass Index, and Quality of Life—Reply. JAMA. 2002;287(17):2210-2211. doi:10.1001/jama.287.17.2209