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May 1, 2002

Postmenopausal Hormone Replacement, Body Mass Index, and Quality of Life—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;287(17):2210-2211. doi:10.1001/jama.287.17.2209

In Reply: In response to Drs Rodriquez and Calle, only 28% of the women enrolled in HERS had a BMI of 25 kg/m2 or less, and only 5% had a BMI of 20.9 kg/m2 or less. We examined the quality-of-life measures in 3 strata of BMI: 25 kg/m2 or less, more than 25 through 30 kg/m2, and more than 30 kg/m2. Overall quality of life scores declined significantly with increasing BMI. None of the tests for interaction between treatment assigned, follow-up time, and BMI were statistically significant, however, and there were no consistent trends between BMI and an effect of hormone therapy on quality of life.

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