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Letters
May 8, 2002

Hormone Replacement Therapy and Risk of Breast Cancer

JAMA. 2002;287(18):2360-2361. doi:10.1001/jama.287.18.2359

To the Editor: Dr Chen and colleagues1 found that use of hormone replacement therapy (HRT) for 20 to 60 months within the previous 5 years increased the incidence of breast cancer by 60% to 85%. They also found that current use of estrogens doubled the risk of lobular breast cancer, but current use of estrogen plus progestin combination increased the risk 4-fold, or twice as much again.

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