To the Editor: Dr Chen and colleagues1 found that use of hormone replacement therapy (HRT)
for 20 to 60 months within the previous 5 years increased the incidence of
breast cancer by 60% to 85%. They also found that current use of estrogens
doubled the risk of lobular breast cancer, but current use of estrogen plus
progestin combination increased the risk 4-fold, or twice as much again.
Grant ECG. Hormone Replacement Therapy and Risk of Breast Cancer. JAMA. 2002;287(18):2360-2361. doi:10.1001/jama.287.18.2359