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Letters
May 8, 2002

Hormone Replacement Therapy and Risk of Breast Cancer

JAMA. 2002;287(18):2360-2361. doi:10.1001/jama.287.18.2359

To The Editor: Dr Chen and colleagues1 reported that recent long-term HRT was associated with an increased risk of breast cancer, and that such HRT was related particularly to lobular tumors.

Table 1 of their article shows that 30.8% of the cases and 32.4% of the controls had histories of surgical menopause, and for these women Table 3 shows that oral HRT within the past 5 years was associated with a significant increase in the risk of breast cancer across durations of HRT ranging from less than 18 months (odds ratio [OR], 1.75) to more than 57 months (OR, 2.45; P = .003 for trend). For women with histories of natural menopause, however, Table 3 shows less evidence of an increase in the risk of breast cancer across durations of oral HRT ranging from less than 18 months (OR, 0.92) to more than 57 months (OR, 1.41; P = .10 for trend).

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