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Letters
May 15, 2002

Skeletal Muscle Glucocorticoid Receptor Density and Insulin Resistance

Author Affiliations
 

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;287(19):2505-2506. doi:10.1001/jama.287.19.2502

To the Editor: In Cushing syndrome, elevated plasma cortisol levels cause insulin resistance, hyperglycemia, hypertension, and dyslipidemia. In patients without Cushing syndrome, these cardiovascular risk factors are associated with more subtle elevations in plasma cortisol concentrations1 and enhanced tissue responsiveness to glucocorticoids.2 We explored the possibility that insulin resistance in patients without Cushing syndrome involves dysregulation of glucocorticoid receptor (GR) expression in muscle.

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