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June 19, 2002

When Should Perioperative β-Blockers Be Discontinued?—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;287(23):3079-3080. doi:10.1001/jama.287.23.3077

In Reply: In response to Drs Silverstein and Tagliente, because Shammash et al1 did not separate patients who had long-term β-blockers discontinued from those who had perioperative β-blockers discontinued, it is indeed unclear what led to mortality in their findings. For example, it is possible that the excess mortality they observed was a result of so-called rebound from β-blockers, removal of the protective effect of perioperatively administered β-blockers, or withdrawal of the protective effect of chronically administered β-blockers.

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