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June 26, 2002

Depression in an Elderly Man

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;287(24):3210-3211. doi:10.1001/jama.287.24.3206

To the Editor: In his Clinical Crossroads article about a 75-year-old man with depression, Dr Kroenke1 briefly mentions that depression sometimes may be secondary to hormonal dysfunction, such as thyroid or adrenal abnormalities. It is curious that he did not consider the possibility of low testosterone level, which also can lead to depression and loss of libido. Hypotestosteronemia, whether age-related or due to other factors, could certainly account for the patient's loss of interest in usual activities, lack of concentration, loss of appetite, hypersomnia, and possibly his cardiac disease, hyperlipidemia, and benign prostatic hyperplasia.2

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