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July 3, 2002

Raloxifene and Risk of Cardiovascular Events—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;288(1):42-43. doi:10.1001/jama.288.1.42

In Reply: Dr Mayer suggests that our criteria for coronary heart disease (CHD) are arbitrary. In fact, each variable listed is an established CHD risk factor. The 10-year risk for heart disease with diabetes is an equivalent to a prior CHD event; a "CHD risk equivalent" according to the National Cholesterol Education Program Adult Treatment Panel III.1 Our Figure 2, showing increasing event rates with increasing scores, supports the appropriateness of the weighting.

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