Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor
Copyright 2002 American Medical Association. All Rights Reserved.
Applicable FARS/DFARS Restrictions Apply to Government Use.2002
To the Editor: Human immunodeficiency virus
1 (HIV-1) antigen-specific proliferative CD4+ T cell responses
are typically absent in patients with chronic HIV-1 infection.1
However, these responses are present in so-called long-term nonprogressors
who experience control of viremia even without treatment1- 3
and in patients treated with highly active antiretroviral therapy (HAART)
during acute seroconversion who are subsequently able to contain viremia after
treatment interruptions.4 These findings
suggest that the presence of CD4+ T cell proliferative responses
to HIV-1 may be associated with protection against viral replication.
Blankson JN, Gallant JE, Quinn TC, Bartlett JG, Siliciano RF. Loss of HIV-1–Specific Immunity During Treatment Interruption in 2 Chronically Infected Patients. JAMA. 2002;288(2):162-164. doi:10.1001/jama.288.2.162