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July NaN, 2002

St John's Wort and Depression

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;288(4):446-449. doi:10.1001/jama.288.4.446

To the Editor: Dr Davidson and colleagues1 reported equivalence between hypericum, sertraline, and placebo in the treatment of depression. The only difference between groups was a significantly better outcome on the Clinical Global Impressions–Improvement Scale (CGI-I) for the sertraline group compared with placebo. The CGI-I is a 1-question measure that assesses change across time.2 The limited data on the CGI-I indicate that it has poor psychometric qualities,3 which is not surprising, given the brevity of the measure.

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