Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor
Copyright 2002 American Medical Association. All Rights Reserved.
Applicable FARS/DFARS Restrictions Apply to Government Use.2002
To the Editor: Dr Davidson and colleagues1 compared the decrease in the HAM-D total scores
by fitting a linear trend to each treatment group. However, Priest et al2 found that depression recovery scores follow an
exponential curve. Therefore, a linear model may be inappropriate. In any
event, full response to treatment was defined as a HAM-D score of 8 or lower
and a CGI I score of 2 or lower. According to the rate ratios, placebo was
33% better than hypericum and 29% better than sertraline. The authors do not
explain how sertraline can have been superior to placebo (P = .02) in the CGI-I scale.
Völp A. St John's Wort and Depression. JAMA. 2002;288(4):446-449. doi:10.1001/jama.288.4.446