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July NaN, 2002

St John's Wort and Depression

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;288(4):446-449. doi:10.1001/jama.288.4.446

To the Editor: Dr Davidson and colleagues1 compared the decrease in the HAM-D total scores by fitting a linear trend to each treatment group. However, Priest et al2 found that depression recovery scores follow an exponential curve. Therefore, a linear model may be inappropriate. In any event, full response to treatment was defined as a HAM-D score of 8 or lower and a CGI I score of 2 or lower. According to the rate ratios, placebo was 33% better than hypericum and 29% better than sertraline. The authors do not explain how sertraline can have been superior to placebo (P = .02) in the CGI-I scale.

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