Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor
In Reply: In response to Dr Jonas, we believe
that the design of the trial by Davidson et al1
represents the potentially correct strategy to answer the question concerning
hypericum's efficacy. However, the actual results have led to profound skepticism
about the design. The major lesson of this study, as reflected by Jonas, is
the need to pay better attention to several concerns.
Kupfer DJ, Frank E. St John's Wort and Depression—Reply. JAMA. 2002;288(4):446-449. doi:10.1001/jama.288.4.446