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July NaN, 2002

Accuracy of Tablet Splitting by Elderly Patients

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;288(4):451-452. doi:10.1001/jama.288.4.446

To the Editor: The cost of some medication regimens can be decreased by as much as 50% if patients split high-dose tablets to achieve an intended lower dose.1 Some studies have concluded that tablet splitting does not affect compliance.1 On the other hand, actual dosages of hand-split tablets may deviate by more than 20%, and some patients may be willing to pay more to avoid splitting.1,2 Another study, however, found that splitting lisinopril did not change control of stable hypertension, and most patients were willing to split tablets.3 Nonetheless, a recent literature review concluded available literature was too limited to adequately address the safety of this practice.4

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