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August 7, 2002

Modes of Transmission of Hemorrhagic Fever

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;288(5):571. doi:10.1001/jama.288.5.571

To the Editor: In their Consensus Statement, Dr Borio and colleagues1 briefly mention Kyasanur Forest disease virus (KFDV), which occurs in a remote part of the world. In 1957, 2 of my colleagues and I were accidentally infected with KFDV while engaged in vaccine preparation.2 Despite our adherence to all of the then-current laboratory precautions, including wearing a face mask, face shield, and gown and working in individual vented cubicles, emulsification of infected tissues created an aerosol that resulted in clinical illness. This incident is evidence that KFDV, although transmitted in nature by a tick bite, is indeed infectious as an aerosol.

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