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August 14, 2002

Dairy Products and Insulin Resistance

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;288(6):693-694. doi:10.1001/jama.288.6.693

To the Editor: Dr Pereira and colleagues1 found an inverse relationship between dairy consumption and the insulin resistance syndrome. It is conceivable that this relationship may be mediated in part by parathyroid hormone (PTH), which can act on adipocytes to increase their intracellular free calcium levels.2 Such an increase can impair glucose transport protein 4 (GLUT-4) function in adipocytes, which renders insulin-stimulated glucose uptake less efficient,2 can impede catecholamine-stimulated lipolysis; and can promote de novo lipogenesis.3 The former effect may promote systemic insulin resistance while the latter effects may increase risk for weight gain.3

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