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August 14, 2002

Effects of Counterregulatory Hormones in a High–Glycemic Index Diet

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;288(6):695. doi:10.1001/jama.288.6.693

To the Editor: Dr Ludwig reviewed the glycemic index and its possible role in the establishment and maintenance of insulin resistance.1 However, in the section addressing the mechanisms by which a high–glycemic index diet may precipitate cardiovascular disease, he did not address the cardiovascular effects of counterregulatory hormones and fatty acids. Such substances may be related to chronically increased autonomic tone,2 which has many of the same long-term consequences as insulin resistance.

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