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August 14, 2002

Effects of Counterregulatory Hormones in a High–Glycemic Index Diet—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;288(6):695. doi:10.1001/jama.288.6.693

In Reply: I agree with Dr Brotman that the increased serum concentrations of counterregulatory hormones and free fatty acids postulated to occur on a high glycemic index diet might alter autonomic tone and thereby increase risk for cardiovascular disease. In addition, glucocorticoids and catecholamines could have direct toxic effects on the heart or blood vessels.1,2 Although beyond the scope of my review, these hormones might also affect neurobehavioral functioning.3

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