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August 14, 2002

Mineral Metabolism and Vascular Disease in Patients With End-Stage Renal Failure—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;288(6):695-696. doi:10.1001/jama.288.6.693

In Reply: Dr Rowe notes that we incorporated measures of mineral metabolism in our investigation. Although one of our a priori assumptions was that calcium, phosphorus, and possibly PTH levels would correlate with pulse pressure, the strength of these associations was weak. In the multivariable model of pulse pressure, the association of phosphorus concentrations had a low χ2 value, calcium levels were not significantly related after adjustment for multiple comparisons, and PTH levels were not significantly associated.

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