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September 18, 2002

Testing for Human Papillomavirus in Women With Abnormal Pap Smear Results

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;288(11):1350. doi:10.1001/jama.288.11.1350

To the Editor: In the new Bethesda Consensus Guidelines,1 HPV DNA testing is the "preferred" approach to evaluating ASC-US when liquid-based cytology is used for screening. Human papillomavirus testing is an attractive alternative to colposcopy and detects most cases of cervical intraepithelial neoplasia (CIN) 2 or higher without subjecting all women with ASC-US to colposcopy.2 Most clinicians, however, perform repeat cytologic testing 3 to 6 months after a single ASC-US result.3 The differences between HPV testing vs repeat cytology, therefore, require scrutiny.

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