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September 18, 2002

Testing for Human Papillomavirus in Women With Abnormal Pap Smear Results

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor


Copyright 2002 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2002

JAMA. 2002;288(11):1350. doi:10.1001/jama.288.11.1350

To the Editor: In the new Bethesda Consensus Guidelines,1 HPV DNA testing is the "preferred" approach to evaluating ASC-US when liquid-based cytology is used for screening. Human papillomavirus testing is an attractive alternative to colposcopy and detects most cases of cervical intraepithelial neoplasia (CIN) 2 or higher without subjecting all women with ASC-US to colposcopy.2 Most clinicians, however, perform repeat cytologic testing 3 to 6 months after a single ASC-US result.3 The differences between HPV testing vs repeat cytology, therefore, require scrutiny.

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