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October 16, 2002

β-Blocker Therapy and Depression

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;288(15):1845-1846. doi:10.1001/jama.288.15.1845

To the Editor: In their review article, Dr Ko and colleagues1 found no significant increased risk of depressive symptoms and only small increased risk of fatigue and sexual dysfunction associated with β-blocker therapy. They concluded that concerns about depression, fatigue, and sexual dysfunction should not deter physicians from initiating β-blocker therapy. I would like to raise the following caveats.

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