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Lab Reports
January 4, 2012

Brain Repair

JAMA. 2012;307(1):24. doi:10.1001/jama.2011.1905

Transplanted immature brain neurons from healthy mouse embryos can partially normalize metabolism in adult mice with morbid obesity caused by a genetic deficiency, according to research led by scientists from Harvard University and Harvard Medical School (Czupryn A et al. Science. 2011;334[6059]:1133-1137).

The researchers transplanted immature neurons from the hypothalamus of normal mouse embryos into the hypothalamus of adult obese mice lacking a receptor for leptin, a weight-regulating hormone. The donor neurons differentiated into several distinct neuronal types that formed functional connections in the brains of the obese mice.

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