Thyroid tumors carrying mutations in the BRAF gene depend on the mutant protein produced by the gene, and inhibiting the gene leads to tumor regression in mice, a new study shows (Chakravarty D et al. J Clin Invest. doi:10.1172/JCI46382 [published online November 21, 2011]).
BRAF gene mutations are found in about one-quarter of papillary carcinomas, the most common form of thyroid cancer, and are even more common in high-grade carcinomas, particularly those that resist radioiodine treatment.
Hampton T. Target for Thyroid Cancer. JAMA. 2012;307(1):24. doi:10.1001/jama.2011.1907