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The World in Medicine
August 17, 2011

Genetic Risk for HCV

JAMA. 2011;306(7):694. doi:10.1001/jama.2011.1156

Japanese researchers have found a gene variant associated with development of liver cancer in carriers of hepatitis C virus (HCV) (Miki D et al. Nat Gen. 10.1038/ng.876 [published online ahead of print July 3, 2011]).

The researchers conducted a genome-wide study, analyzing 467 538 genetic variants from 212 Japanese individuals with chronic HCV infection who developed hepatocellular carcinoma (HCC) and 765 individuals with chronic HCV without HCC. They found 1 variant, located in a gene called DEPDC5, associated with an increase in HCC risk, a finding confirmed in an independent case-control population (710 cases and 1625 controls). When the results were adjusted for age, sex, and platelet count, the variant was found to almost double the risk of developing HCC.

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