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August 24/31, 2011

Major Birth Defects After Exposure to Newer-Generation Antiepileptic Drugs—Reply

Author Affiliations

Author Affiliation: Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark (Dr Hviid) (

JAMA. 2011;306(8):826-827. doi:10.1001/jama.2011.1186

In Reply: Ms Merry and colleagues and Dr Tomson and colleagues think that the conclusion of the study was overstated. I disagree. The conclusion reflected the study results: no association was found between newer-generation antiepileptic drugs and major birth defects. The conclusion was not that newer-generation antiepileptic drugs were safe, and it was clearly stated that especially for topiramate, gabapentin, and levetiracetam, only moderate to large risk increases could be excluded.

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