A newly synthesized novel family of flavonoid-like molecules has broad activity against a variety of bacteria and fungi but limited toxicity to mammalian cells, according to a recent study (Fowler ZL et al. PLoS ONE. 2011;6:e25681).
Naturally occurring flavonoids are known to be microbial deterrents and anti-infection agents in plants. Researchers used the natural flavonoid scaffold to synthesize nonnatural flavanone molecules and evaluated their antimicrobial effects on 2 types of bacteria (Escherichia coli and Bacillus subtilis) and the fungal pathogens Cryptococcus neoformans and Aspergillus fumigatus.
Hampton T. New Antimicrobials. JAMA. 2011;306(21):2315. doi:10.1001/jama.2011.1740