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Lab Reports
December 7, 2011

New Antimicrobials

JAMA. 2011;306(21):2315. doi:10.1001/jama.2011.1740

A newly synthesized novel family of flavonoid-like molecules has broad activity against a variety of bacteria and fungi but limited toxicity to mammalian cells, according to a recent study (Fowler ZL et al. PLoS ONE. 2011;6[10]:e25681).

Naturally occurring flavonoids are known to be microbial deterrents and anti-infection agents in plants. Researchers used the natural flavonoid scaffold to synthesize nonnatural flavanone molecules and evaluated their antimicrobial effects on 2 types of bacteria (Escherichia coli and Bacillus subtilis) and the fungal pathogens Cryptococcus neoformans and Aspergillus fumigatus.

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