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Lab Reports
December 7, 2011

Anti-HIV Antibody Structure

JAMA. 2011;306(21):2315. doi:10.1001/jama.2011.1742

A team led by researchers at the Scripps Research Institute, in La Jolla, Calif, has uncovered the crystal structure of a region of the potent anti-HIV antibody PGT 128 in complex with an HIV envelope protein (Pejchal R et al. Science. doi:10.1126/science.1213256 [published online ahead of print October 13, 2011]). This antibody can neutralize about 70% of globally circulating HIV strains by blocking their ability to infect cells, and it can do so at lower concentrations than any previously reported broadly neutralizing anti-HIV antibody.

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