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Lab Reports
December 7, 2011

Narcolepsy and Weight Gain

JAMA. 2011;306(21):2315. doi:10.1001/jama.2011.1743

A new study may help explain why individuals with narcolepsy tend to gain weight even when they eat less than the average person (Sellayah D et al. Cell Metab. 2011;14[4]:478-479).

An association between obesity and narcolepsy was first noted about 8 decades ago. Patients with narcolepsy are often deficient in the neuropeptide hormone orexin, which encourages hunger and wakefulness. This deficiency may be the result of impaired energy-burning brown fat. (While white fat stores calories, brown fat burns them, generating heat in the process.)

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