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Global Health
December 21, 2011

Genetic Susceptibility to Dengue

JAMA. 2011;306(23):2553. doi:10.1001/jama.2011.1809

Two genetic variants associated with susceptibility to dengue shock syndrome (DSS) have been identified through a genome-wide association study by southeast Asian researchers (Khor CC et al. Nat Genet. 10.1038/ng.960 [published online ahead of print October 16, 2011]).

Certain populations are more susceptible to severe dengue, which is characterized by increased vascular permeability, and can lead to life-threatening hypovolemic shock. To investigate the genetic underpinnings of this susceptibility, the investigators compared the genomes of 2008 children with severe dengue in Vietnam against 2018 population control cases. They identified DNA variations in 2 genes— MICB and PLCE1 —that increased a child's susceptibility to DSS and replicated their findings in a follow-up sample of 1737 cases and 2934 controls.

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