Physicians should be particularly wary of using linezolid or methylene blue in patients taking selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs) because the interaction might trigger serotonin syndrome, warns the US Food and Drug Administration (FDA). Such a combination may lead to a toxic buildup of serotonin in the brain and cause confusion, hyperactivity, impaired memory, and other problems.
Kuehn BM. Serotonin Syndrome Update. JAMA. 2011;306(24):2661. doi:10.1001/jama.2011.1868