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Lab Reports
February 1, 2012

Experimental Ebola Vaccine

JAMA. 2012;307(5):446. doi:10.1001/jama.2012.71

A research team led by scientists at Arizona State University in Tempe has engineered a candidate vaccine that protects mice against Ebola hemorrhagic fever (Phoolcharoen W et al. Proc Natl Acad Sci U S A. 2011;108[51]:20695-20700). This vaccine, which includes the Ebola viral surface glycoprotein fused to a monoclonal antibody that recognizes the glycoprotein, was injected into mice along with polyinosinic:polycytidylic acid (PIC), a chemical that activates a biochemical cascade involved in innate immunity.

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