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Lab Reports
March 7, 2012

Heart Failure’s Link to Diabetes

JAMA. 2012;307(9):904. doi:10.1001/jama.2012.221

When the researchers disrupted p53 activation in adipose tissue, mice experienced less inflammation, reduced insulin resistance, and less heart dysfunction.

The results indicate that inhibition of p53-induced adipose inflammation is a potential target for treating metabolic abnormalities and cardiac dysfunction in patients with heart failure.

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