[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Views 68
Citations 0
Lab Reports
March 7, 2012

Quick Hit of Opioids

JAMA. 2012;307(9):904. doi:10.1001/jama.2012.223

A recent study performed in rats indicates that a brief high dose of opioid drugs may erase memory traces of pain in the spinal cord (Drdla-Schutting R et al. Science. 2012;335[6065]:235-238).

Opioids exert their pain-relieving effects by binding to μ-opiate receptors on nerve cells. Opioids are generally given continuously in moderate doses to achieve permanent binding to these receptors because the drugs are thought to alleviate pain only while bound.

First Page Preview View Large
First page PDF preview
First page PDF preview