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Article
March 31, 1917

ALKALINE TREATMENT OF EARLY GALLBLADDER CARRIERSWITH OBSERVATIONS ON THEIR DETECTION BY AID OF THE DUODENAL TUBE

Author Affiliations

Major, Medical Corps, United States Army EL PASO, TEXAS

From the Laboratory Service of the U. S. Army Letterman General Hospital, San Francisco, and Southern Department Laboratory No. 2, El Paso, Texas.

JAMA. 1917;LXVIII(13):958-961. doi:10.1001/jama.1917.04270030290004
Abstract

Gallbladder carriers include carriers of the typhoid group, cholera carriers and probably also bacillary dysentery carriers. I have called attention1 to the problem of the pathogenesis of gallbladder lesions in these diseases, and have emphasized the mechanism of descending infection of the bile from the liver. It was shown by means of the common duct fistula method in rabbits that more typhoid bacilli appear in the bile with larger intravenous doses; that more bacilli appear after mesenteric than after ear vein injections; that more bacilli appear in immunized animals than in normal animals, and that more actual gallbladder infections occur under these conditions, which favor the

presence of micro-organisms in the bile, than otherwise.

The mechanism of infection in the case of typhoid, cholera and dysentery organisms seems, therefore, to be different from that in case of the streptococci which, as has recently been shown by Rosenow,2 seem

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