Some tumors secrete vascular endothelial growth factor D (VEGF-D), a protein that induces the formation of new lymphatics from preexisting vessels to facilitate cancer spread. The mechanisms underlying cancer's spread via the lymph nodes with the help of VEGF-D have remained elusive, but now investigators in Australia have found that the protein modulates the production of prostaglandins, which are important regulators of lymphatic vessel dilation (Karnezis T et al. Cancer Cell. 2012;21:181-195).
Hampton T. NSAIDs and Cancer Spread. JAMA. 2012;307(13):1357. doi:10.1001/jama.2012.373