Author Affiliation: Department of Medicine, University of Padova, Padova, Italy (email@example.com).
To the Editor: Dr Nauman and colleagues1 presented data from a large Norwegian cohort studied twice 10 years apart (Nord-Trøndelag County Health Study [HUNT-1 and HUNT-2]) on the association of changes in resting heart rate (RHR) with mortality from ischemic heart disease. The authors found that the association was not linear and that a decrease in RHR at the second measurement showed no mortality benefit. This finding is at variance with previous results by others who showed that a RHR decrease during 5 years of observation was associated with a decreased risk for mortality of 14%.2
Palatini P. Changes in Resting Heart Rate Over Time and Mortality. JAMA. 2012;307(13):1369–1370. doi:10.1001/jama.2012.391