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April 4, 2012

Recommendations on Use of Prostate-Specific Antigen for Prostate Cancer Screening—Reply

Author Affiliations

Author Affiliations: Division of General Medicine, Geriatrics, and Palliative Care, University of Virginia School of Medicine, Charlottesville (Dr Wolf); and Department of General Internal Medicine, University of Texas MD Anderson Cancer Center, Houston (Dr Volk) (

JAMA. 2012;307(13):1372-1374. doi:10.1001/jama.2012.397

In Reply: We agree with many of Dr Garnick's points. However, he appears to have overlooked our affirmation of the known harms associated with prostate cancer screening:

Regardless of the controversy surrounding the question of benefit, there is unanimity in the estimation of harm. All agree that men face serious risks from diagnostic testing and treatment of screen-detected prostate cancers, ranging from sexual, urinary, and bowel injury to treatment-related death. Moreover, many men who are diagnosed with and treated for prostate cancer have cancers that were never destined to harm them . . . .

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