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April 4, 2012

Recommendations on Use of Prostate-Specific Antigen for Prostate Cancer Screening—Reply

Author Affiliations

Author Affiliations: Department of Urology, University of Michigan, Ann Arbor (

JAMA. 2012;307(13):1372-1374. doi:10.1001/jama.2012.399

In Reply: There is no question that much uncertainty exists around the role of PSA-based early detection of prostate cancer. However, our position that PSA should not be eliminated as a screening tool was based on several facts. First, population-based modeling data suggest that widespread implementation of PSA screening explains a substantial fraction of recent declines in prostate cancer mortality in the United States.1

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