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April 11, 2012

CYP2C19 Genotype and Cardiovascular Events

Author Affiliations

Author Affiliations: Department of Cardiology, University of Athens Medical School, Athens, Greece (chstefan@med.uoa.gr).

JAMA. 2012;307(14):1482-1485. doi:10.1001/jama.2012.445

To the Editor: The article by Dr Holmes and colleagues1 appraised the evidence on the association between CYP2C19 genotype and clopidogrel response through a systematic review and meta-analysis. Their results showed that although there was an association between the CYP2C19 genotype and clopidogrel responsiveness, overall there was no significant association of genotype with cardiovascular events.

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