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April 11, 2012

Cardiovascular Events in Adults Taking Medications for ADHD—Reply

Author Affiliations

Author Affiliations: Division of Research, Kaiser Permanente Northern California, Oakland (Drs Habel and Mr Fireman) (; and Department of Pediatrics, Vanderbilt University, Nashville, Tennessee (Dr Cooper).

JAMA. 2012;307(14):1485-1486. doi:10.1001/jama.2012.449

In Reply: We acknowledge that our study had limited ability to examine the risk of cardiovascular events associated with long-term use of ADHD medications. Yet our data suggest that most adult use of ADHD medications is relatively short-term. Among the approximately 50% of our study cohort who were new users at cohort entry, 75% had less than 8 months of use; 75% of the prevalent users had less than 15 months of use during follow-up. Nonetheless, some of the prevalent users may have taken ADHD medications for several years. In subgroup analyses, we did not find any evidence of elevated risk among the prevalent users.

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