Author Affiliations: Division of Research, Kaiser Permanente Northern California, Oakland (Drs Habel and Mr Fireman) (email@example.com); and Department of Pediatrics, Vanderbilt University, Nashville, Tennessee (Dr Cooper).
In Reply: We acknowledge that our study had limited ability to examine the risk of cardiovascular events associated with long-term use of ADHD medications. Yet our data suggest that most adult use of ADHD medications is relatively short-term. Among the approximately 50% of our study cohort who were new users at cohort entry, 75% had less than 8 months of use; 75% of the prevalent users had less than 15 months of use during follow-up. Nonetheless, some of the prevalent users may have taken ADHD medications for several years. In subgroup analyses, we did not find any evidence of elevated risk among the prevalent users.
Habel LA, Fireman B, Cooper WO. Cardiovascular Events in Adults Taking Medications for ADHD—Reply. JAMA. 2012;307(14):1485-1486. doi:10.1001/jama.2012.449