In Reply: In response to Drs Spaeth and Mantravadi, the efficacy of topiramate in treating alcoholism in our study compared favorably against the generally mild to moderate adverse events that participants encountered. No incidence of secondary angle-closure glaucoma was reported in either this study or the other topiramate study we conducted1; however,
we do agree that patients should be advised of this rare but serious adverse effect.
Johnson BA, Ait-Daoud N, Anton RF, Ciraulo DA, Kranzler HR, Mann K, O’Malley SS, Swift RM. Topiramate as Treatment for Alcohol Dependence—Reply. JAMA. 2008;299(4):405-407. doi:10.1001/jama.299.4.406