In Reply: Dr Stringer and colleagues raise concerns about generalizability of the results of the study by Johnson et al to clinical populations. This study was an efficacy trial and as such required stringent inclusion and exclusion criteria,
which limit external validity. Effectiveness trials in community settings and with broad inclusion are indeed needed, but such studies are expensive,
lengthy, and difficult, limiting the number of questions that can be addressed in this way.
Willenbring ML. Topiramate as Treatment for Alcohol Dependence—Reply. JAMA. 2008;299(4):405-407. doi:10.1001/jama.299.4.407-a