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The World in Medicine
January 14, 1998

Gene for Autoimmunity

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JAMA. 1998;279(2):101. doi:10.1001/jama.279.2.101

In their quest to clone the first gene solely responsible for an autoimmune response, 2 international research teams have raced to a tie.

Both groups—one from Finland and Germany and the other from Japan, Switzerland, and Finland—independently described their work in cloning and characterizing the gene that is responsible for autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) in the December issue of Nature Genetics. APECED destroys the function of such endocrine organs as the parathyroid gland, thyroid gland, adrenal cortex, ovaries, and testes.

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