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Lab Reports
October 3, 2007

Healthy Obese Mice

JAMA. 2007;298(13):1506. doi:10.1001/jama.298.13.1506-a

A novel model of morbid obesity associated with an improved metabolic profile may help explain why not all obese people are diabetic, according to a study led by scientists at the University of Texas Southwestern Medical Center, in Dallas (Kim JY et al. J Clin Invest. doi:10.1172/jci31021 [published online ahead of print August 23, 2007]). The study found that obese mice with an abundance of the hormone adiponectin and a lack of another hormone, leptin, do not develop insulin resistance. While adiponectin controls sensitivity to insulin, leptin curbs appetite.

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