Mounting evidence indicates that dual anticoagulation and antiplatelet therapy is no more effective than monotherapy in treating a variety of cardiovascular conditions, but it does increase the risk of life-threatening bleeding.
“What's interesting is that while clinicians are aware of the potential bleeding complications with these antithrombotic drugs, they do not appreciate that the risk is not purely additive; it is synergistic,” said James M. Brophy, MD, PhD, associate professor of medicine in the Division of Cardiology and Clinical Epidemiology at McGill University Health Centre, in Montreal.
Mitka M. Dual Antithrombotic Therapy’s Increased Risks Not Always Offset by Benefit. JAMA. 2007;298(13):1504-1505. doi:10.1001/jama.298.13.1504