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Medical News and Perspectives
October 3, 2007

Dual Antithrombotic Therapy’s Increased Risks Not Always Offset by Benefit

JAMA. 2007;298(13):1504-1505. doi:10.1001/jama.298.13.1504

Mounting evidence indicates that dual anticoagulation and antiplatelet therapy is no more effective than monotherapy in treating a variety of cardiovascular conditions, but it does increase the risk of life-threatening bleeding.

“What's interesting is that while clinicians are aware of the potential bleeding complications with these antithrombotic drugs, they do not appreciate that the risk is not purely additive; it is synergistic,” said James M. Brophy, MD, PhD, associate professor of medicine in the Division of Cardiology and Clinical Epidemiology at McGill University Health Centre, in Montreal.

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