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January 21, 1998

Nicotine Replacement Therapy and Smoking Reduction as an Interim Goal

Author Affiliations

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor


Copyright 1998 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1998

JAMA. 1998;279(3):194-195. doi:10.1001/jama.279.3.193

To the Editor.— Dr Warner and colleagues1 questioned whether users of nontobacco nicotine delivery products also would use conventional tobacco products. They noted that over-the-counter availability of nicotine-containing pharmaceuticals would likely increase the use of these products as partial substitutes for smoking.

Even prior to their over-the-counter availability, nicotine-containing pharmaceuticals have been used in combination with conventional tobacco products in studies of smoking cessation.25 The particular type of allowed combination has varied widely. During an investigation of nicotine skin patches, participants could smoke an average of 1 cigarette per day over 4 weeks.2 Similarly, participants in an 8-week trial of transdermal nicotine patches who reported irregular or intermittent smoking were allowed to continue using the medication provided they continued to try to quit smoking.3

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